Big Brains

What if we could precisely measure a cell at its most fundamental level? In this episode, we talk with the University of Chicago scientist Peter Maurer about how he and his colleagues made the breakthrough discovery of turning a protein found in living cells into the first biological quantum bit, also known as a qubit.

Maurer explains how quantum systems—once thought to be too fragile for real-world use—are becoming some of the most powerful sensors ever built, and what they could teach us about the brain, the body and more.

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We've all heard the phrase "Manifest Your Destiny" when it comes to wanting a new promotion, figuring out a new career path or just trying to achieve that long-term goal. It turns out that the act of manifestation is not merely pseudoscience—it actually has a body of research in neuroscience to back it up.

James Doty was a clinical professor of neurosurgery at Stanford University, and founder and director of the Center for Compassion and Altruism Research and Education. He wrote several books, including Mind Magic: The Neuroscience of Manifestation and How It Changes Everything.

The internet and social media have transformed the way in which we hear and understand music today—and online communities and platforms from YouTube to TikTok have changed how music circulates and ultimately goes viral. Why do some pop stars have more success creating hit songs and building online following than others?

In this episode, we speak with Paula Clare Harper, a musicologist and assistant professor at the University of Chicago. Harper co-edited the book Taylor Swift: The Star, The Songs, The Fans, which explores the online musical cultures that produced and propelled the image of megastar Ta...

Can you imagine a world in which a wearable device, like a smartwatch, could move your fingers to strum the guitar or play the drums? That kind of technology is part of the innovative research coming out of the Human-Computer Integration Lab at the University of Chicago, led by renowned computer scientist Pedro Lopes. His lab is developing a new generation of gadgets that use haptics (or tactile sensations like the buzz of your smartphone) to move your body, replicate your sense of smell and even make you feel things.

In this episode, Lopes explores the potential...

More and more women in the United States are saying no to motherhood. In 2023, the U.S. fertility rate reached the lowest number on record. But the idea of non-motherhood is actually not a new phenomenon, nor did it come out of the modern feminist movement. For centuries, women have made choices about limiting births and whether or not to become mothers at all. This history is documented in a new book, "Without Children: The Long History of Not Being a Mother," by University of Chicago Assistant Instructional Professor Peggy O'Donnell Heffington.

Heffington writes about the historic...

What does it mean to see beneath the surface — of the human body, the brain, or even the universe itself? In his new book, The Future of Seeing: How Imaging Is Changing Our World, Prof. Daniel Sodickson of NYU explores the future of imaging: How technology is transforming not just medicine, but our very ways of perceiving the world. With the rise of AI-driven “digital vision,” Sodickson, a pioneer of MRI innovation, argues that imaging is no longer just a diagnostic tool — it’s becoming a new language of discovery.

In this conversation, Sodickson explores the promises and pitfal...

Few ideas have gripped the public imagination quite like the idea of the “psychopath.” From Hollywood thrillers to true-crime podcasts, popular culture has led us to believe that psychopaths are dangerous and biologically distinct from the rest of us. But what if almost everything we think we know about them is wrong?

In this episode, we talk with Rasmus Rosenberg Larsen, an Assistant Professor of Forensic Epistemology at the University of Toronto and author of "Psychopathy Unmasked," whose research is challenging the very foundation of psychopathy as a diagnosis. Larsen explains how the term “psychopath” is relatively new, dat...

For decades, neuroscience has promised breakthroughs in treating conditions like depression, schizophrenia, and Alzheimer’s. Yet despite powerful technologies and billions invested, progress has been frustratingly slow. Why?

On this episode of Big Brains, we talk with Nicole Rust, neuroscientist at the University of Pennsylvania and author of Elusive Cures. Rust argues that the traditional “domino” view of the brain—where one broken piece can simply be fixed—has held us back. Instead, she says we need to embrace the brain’s true nature: a complex, dynamic system more like the weather than a machine.

We explore w...

Billions of years ago, Mars may have looked less like the barren red desert we know today and more like Earth—with a blue sky, flowing rivers, and even seas. What happened to turn a once-habitable world into the frozen, lifeless planet we see now?

On this episode of Big Brains, University of Chicago geophysical scientist Edwin Kite takes us on a journey through Mars’ hidden past. From evidence of a lost carbon cycle to theories about ancient climate swings, Kite’s research is rewriting the story of the Red Planet. But it’s not just about the past...

We’re living in an attention economy—and most of us are broke. But what if the secret to restoring your focus, improving your mental health, and even reducing crime rates wasn’t found in an app or a pill, but in a tree?

In this episode, we speak with University of Chicago psychologist Marc Berman, whose research on “soft fascination” and nature’s cognitive effects is reshaping how we think about everything from urban planning to depression treatment. From groundbreaking hospital studies to surprising results with plastic plants, Berman’s work uncovers the deep—and often invisible—power...

We’ve long marveled at how efficiently plants convert sunlight into energy—but no one guessed they were using quantum mechanics to do it.

In this episode, we speak with Greg Engel, a pioneering biophysicist at the UChicago Pritzker School of Molecular Engineering and the Department of Chemistry who helped launch the field of quantum biology. Engel explains how plants and bacteria evolved to exploit quantum effects for photosynthesis—and how understanding these systems could spark a revolution in quantum sensing, medicine, and neuroscience.

Engel’s team has already built quantum sensors inspired by nature’s designs...

You’ve heard of plastic polluting oceans. But what if it’s polluting you—your brain, your reproductive system, even your unborn children?

In this eye-opening episode, we speak with Prof. Matthew Campen, a scientist at the University of New Mexico, whose latest studies have uncovered evidence of microplastics in placentas, reproductive organs and brains of humans—particularly in the frontal cortex, where decision-making and personality live.

We explore how these plastic particles are entering our bodies (hint: it’s not just your water bottle), what they might be doing to us, and why scientists are just b...

Hello listeners…we're re-releasing one of our favorite Big Brains episodes—an incredibly insightful conversation with psychologist Adam Alter. If you've ever felt stuck in your life or career, this episode offers practical strategies and surprising science to help you move forward.

From why your best ideas might come after you feel like giving up, to what Netflix can teach us about breaking through inertia, this episode is packed with revelations.

We’ll be back with brand-new episodes starting in August—also, check out our new YouTube page where you can now watch video versions of Big B...

One of the benefits of producing this podcast at the University of Chicago is that there are often events on campus that bring in not just one Big Brain, but many in order to find answers to the some of the most complex problems of our time. I recently had the pleasure of hosting one such event on artificial intelligence that we want to share with you today. It was part of the Graham School’s Leadership & Society Initiative Symposium, examined how AI could change everything and, more importantly, whether it should.

Artificial intelligence is evolving faster th...

For a more than a century, the Food and Drug Administration has worked to protect public health. In his research, Harvard University physician-researcher Jerry Avorn has examined how the FDA’s once-rigorous gold standard approval process has been affected by a powerful shortcut known as the Accelerated Approval Program—originally designed for desperate AIDS and cancer patients. He says that change in the 1990s has allowed more than half of all new drugs onto the market before drug companies have proven they actually help people.

In his new book Rethinking Medications: Truth, Power and the Drugs We Take...

Prof. James Evans, a University of Chicago sociologist and data scientist, believes we’re training AI to think too much like humans—and it’s holding science back.

In this episode, Evans shares how our current models risk narrowing scientific exploration rather than expanding it, and explains why he’s pushing for AIs that think differently from us—what he calls “cognitive aliens.” Could these “alien minds” help us unlock hidden breakthroughs? And what would it take to build them?

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When someone we know or love starts to develop psychological issues, we don't often associate it with a form of dementia. However, this trait is one of the most common signs of frontotemporal dementia (FTD) — the most common neurodegenerative disease in people under the age of 65. In his new book, Mysteries of the Social Brain: Understanding Human Behavior Through Science, Dr. Bruce Miller highlights his experiences observing people with FTD and what they have taught him about what he calls the "social brain."

Dr. Bruce Miller has been observing people with FTD for decades in the Memory an...

The search for life beyond Earth is no longer science fiction—it takes a lot of data, powerful telescopes and a bit of cosmic detective work. And at the center of this search is University of Chicago astrophysicist Jacob Bean. Bean was part of the team that made history by detecting carbon dioxide in the atmosphere of a distant planet using the James Webb Space Telescope—a major step forward in our ability to study exoplanets.

Bean uses cutting-edge tools and discoveries that are reshaping how we think about planet habitability, biosignatures and our place in the univ...

Despite decades of policy ideas, pouring millions of dollars into the problem, and a slow pace of gun control measures, the United States hasn’t made much progress on curbing the epidemic of gun violence in our country.

For the past 25 years, Prof. Jens Ludwig of the University of Chicago has examined the questions of: Why does gun violence happen, and is there anything we can do about it?

In his new book, Unforgiving Places: The Unexpected Origins of American Gun Violence, Ludwig—who is director of the University of Chicago Crime Lab—discusses why we've...

What if a single number, derived from your DNA, could predict your income, education level or even who you're likely to marry? In his new book “The Social Genome,” Princeton University sociologist Dalton Conley explores the science behind how our genes are shaping our society in ways that are both profound and unsettling.

Conley explains how our genes, and the genes of those around us, are influencing our lives in ways we barely understand—from fertility clinics selecting embryos based on genetic traits to the rise of “genetic sorting” in everything from dating to zip codes. He also debun...

When we lose someone, we love, we often say we have a broken heart—but what if that’s not just a metaphor?

In her new book “The Grieving Body: How The Stress of Loss Can Be An Opportunity For Healing” University of Arizona Professor of Psychology Mary Frances O’Connor shares groundbreaking insights into the biological and physiological impacts grief has on our bodies. O’Connor reveals how profound loss can lead to serious medical conditions, from heart attacks to immune system breakdowns, and explains why grieving can make us more vulnerable to diseases like cancer, pneumonia, a...

New federal data paints a stark picture: American children are falling behind in reading and test scores, with the gap between advantaged and disadvantaged kids growing wider. But is this really just a problem of money? University of Chicago Developmental psychologist Ariel Kalil has spent her career studying how parents influence childhood development—not just through resources, but through daily habits and interactions.

On this episode, we explore the surprising science behind parental engagement, the behavioral biases that shape parenting decisions, and why simple interventions—like 15 minutes of reading a day—can have an outsized impact. Plus, we dis...

What does it mean to understand death? For centuries, philosophers have argued that only humans can truly comprehend mortality. But what if they’re wrong?

In this episode, we speak with philosopher Susana Monsó, author of Playing Possum: How Animals Understand Death, to explore whether animals can grasp their own mortality. From grieving elephants to corpse-removing ants and possums that play dead, we investigate what animal behavior reveals about their concept of death. Do dogs understand when their owners pass away? Do predators recognize a corpse as different from prey? And what does this mean for how we...

In 2000, the United States declared that measles had been eliminated. But just 15 years later, the disease made a comeback—and it hasn’t gone away since. In this episode, Dr. Adam Ratner, director of the Division of Pediatric Infectious Diseases at NYU and author of Booster Shots: The Urgent Lessons of Measles and the Uncertain Future of Children's Health, explains why measles outbreaks are occurring again—as vaccine hesitancy and the antivax movement is on the rise—and what this means for the future of children’s health.

Ratner describes why measles is the most contagious disease we know of...

What makes a good life? For decades, psychologists have debated whether true fulfillment comes from happiness—a life of comfort and joy—or meaning—a life of purpose and impact. But what if there's a third way?

University of Chicago psychology professor Shigehiro Oishi has spent his career studying happiness, meaning, and what truly brings people deep satisfaction. His new research suggests that some of the most fulfilled people don’t prioritize either—they live psychologically rich lives, full of novelty, challenges, and transformative experiences.

In this episode, Oishi explains why psychological richness might be the missin...

Imagine a future in which Band-Aids talk to your cells, pacemakers are powered by light and your gut microbiome gets a tune-up—all thanks to tiny bioelectric devices. Sounds like sci-fi, right? Think again.

Prof. Bozhi Tian of the University of Chicago is on the frontier of bioelectronics, building living machines that can heal, enhance and maybe even transform what it means to be human. In this episode, he explains his research lab’s work and explores the thrilling, strange and sometimes unsettling world in which biology meets technology.

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Five years after COVID became a global pandemic, could another health crisis be on our horizon? According to scientists who study diseases, the possibility of a fungal pandemic—the subject of science fiction TV shows like “The Last of Us,” could be more of a reality, thanks to climate change and our warming planet. As fungi are adapting to warmer climates, they are becoming increasingly stronger and more resistant against the drugs we have to fight them.

Arturo Casadevall is one of the scientists who is warning against fungi's powerful potential. He's a professor of microbiology and immuno...

As we step into 2025, many of us are thinking about how to turn our New Year's resolutions into lasting changes. But what if the secret to success lies not in willpower but in the words we use every day? To kick off the year, we’re sharing our past episode with Jonah Berger, a professor at The Wharton School and author of Magic Words: What to Say to Get Your Way.

In this episode, Berger uncovers the science behind the language we use and how it shapes our habits, decisions, and relationships. From simple word swaps that ca...

We have long heard the claims that a glass of red wine is good for your heart, but it turns out that the research that fueled this wisdom was actually skewed. Some studies made it appear like moderate drinkers were healthier than people who didn't drink at all, leading the public to believe that alcohol was healthier than it is. While drinking alcohol occasionally might not have catastrophic effects on your health, the data shows that even moderate drinking will reduce your life expectancy.

In this episode, we speak with Tim Stockwell, a scientist at the Canadian...

For centuries, death has been seen as a final, inescapable line—a moment when the heart stops and the brain ceases to function. But revolutionary research asks: What if everything we thought we knew about death was wrong?

Sam Parnia, an associate professor of medicine at NYU Langone, is the author of Lucid Dying: The New Science Revolutionizing How We Understand Life and Death. His groundbreaking work explores how science is pushing the boundaries of life and death, uncovering the potential to resuscitate animals—and maybe one day humans—after they've been declared dead. From recalling experiences of con...

This year’s election might have been the most contentious in modern memory. It's not just that politics have changed, but it seems that people have too. You’ve probably heard this phrase: “People aren’t as kind as they used to be”. Maybe you’ve experienced the feeling that people are acting meaner to each other, year after year. But is it true? Are people really less kind than they used to be?

With that question in mind, and as we take some time off for the Thanksgiving holiday, we wanted to reshare our episode with psychologist...

What if we could predict the economy the way we predict the weather? What if governments could run simulations to forecast the effects of new policies—before they happen? And what if the key to all of this lies in the same chaotic systems that explain spinning roulette wheels and rolling dice?

J. Doyne Farmer is a University of Oxford professor, complexity scientist, and former physicist who once beat Las Vegas casinos using his scientific-based methods. In his recent book “Making Sense of Chaos: A Better Economics for a Better World” Farmer is using those same principles to bui...

https://haarc.center.uchicago.edu/We used to think aging inevitably led to memory loss, but a small group of people—known as SuperAgers—are defying the odds. These individuals, all over 80, have the memory performance of someone in the 50s. The question is: how?

One of the leading experts studying SuperAgers is University of Chicago neurologist Emily Rogalski. She explores the fascinating science behind SuperAgers—uncovering what makes their physical brains different and how their lifestyle choices could be the key to a having a sharper, healthier brain well into old age.

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On Big Brains, we get to speak to a lot of groundbreaking scholars and experts, but some conversations we walk away knowing we’ve just heard from someone who is really changing the world. We certainly felt that way years ago after talking to University of Chicago scholar James Robinson, and it turns out…the Nobel Prize committee agreed in 2024 when it awarded him a share of the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel.

Robinson was honored for the exact work that we talked to him about nearly five years ago. The auth...

How old is the universe—and how fast is it expanding? These are part of one of the biggest—and most contested—questions in science, and the answers could change our understanding of physics.

In this episode, we talk with renowned UChicago astronomer Wendy Freedman, who’s spent decades trying to solve these very questions. There are two ways to measure how fast the universe is expanding, also known as the Hubble constant; Freedman has done groundbreaking research to calculate this number using stars, but the problem is, her numbers don’t match up with scientists using a differen...

One of the biggest questions of every election is: What’s going on with young voters? There is endless speculation on the news about what young people care about, but very little good research examining their views on the candidates and the issues that matter most to them. The first-of-its-kind GenForward Survey changed that when it was created in 2016 at the University of Chicago.

Led by renowned University of Chicago political scientist Cathy Cohen, the survey digs into what is animating young voters—especially young voters of color who are millennials and in Generation Z—and what they t...

More and more women in the United States are saying no to motherhood. Alarmingly, in 2023, the U.S. fertility rate reached the lowest number on record. But the idea of non-motherhood is actually not a new phenomenon, nor did it come out of the modern feminist movement. For centuries, women have made choices about limiting births and whether or not to become mothers at all. This history is documented in a new book, "Without Children: The Long History of Not Being a Mother," by University of Chicago Assistant Instructional Professor Peggy O'Donnell Heffington.

Heffington writes about the...

Race has played a huge role in the creation of mass homeownership in the United States. Discriminatory housing practices including redlining, exclusionary zoning and whitewashing led to great disparities in home ownership among White and Black homeowners. Despite the passage of the Fair Housing Act in 1968, the damage had been done to communities of color and the rates of Black homeownership.

Mass homeownership actually changed the definition, perception and value of race, according to a new book called The Residential is Racial: A Perceptual History of Mass Homeownership. In it, University of Chicago scholar Adrienne Brown documents...

If you’ve spent any time playing with modern AI image generators, it can seem like an almost magical experience; but the truth is these programs are more like a magic trick than magic. Without the human-generated art of hundreds of thousands of people, these programs wouldn’t work. But those artists are not getting compensated, in fact many of them are being put out of business by the very programs their work helped create.

Now, two computer scientists from the University of Chicago, Ben Zhao and Heather Zheng, are fighting back. They’ve developed two programs, called...

In the near future, birth defects, traumatic injuries, limb loss and perhaps even cancer could be cured through bioelectricity—electrical signals that communicate to our cells how to rebuild themselves. This innovative idea has been tested on flatworms and frogs by biologist Michael Levin, whose research investigates how bioelectricity provides the blueprint for how our bodies are built—and how it could be the future of regenerative medicine.

Our podcast is taking a quick summer break, but we wanted to take this time to share some of our favorite episodes with you. One of the most fascinating topi...

Can you heal faster just by tricking your brain? Could you lose weight with only a change of mindset? Could you think yourself into being younger? If you think the answer to all these questions is no, you haven’t read the research from renowned Harvard University psychologist Ellen Langer.

Our podcast is taking a quick summer break, but we wanted to take this time to share some of our favorite episodes with you. The summer is a perfect time to take a step back, evaluate where we are in our lives, and perhaps even create new he...

We've all been stuck at some point in our lives — whether we've been stuck at a job and wanting to make a career change, stuck in a location and wanting to move somewhere new, or stuck in relationships or friendships. But the method to getting “unstuck” and achieving a breakthrough might be easier than you think.

Using research-backed tools, New York University's Adam Alter shares his tips for how to get unstuck in his new book, Anatomy of a Breakthrough. Alter shares success stories from some of the world's most successful people, and explains how altering your though...

There is a science to what we remember and what we don't. For instance, why do we remember certain pieces of artwork, some brands’ logos, or even people's faces? University of Chicago psychologist Wilma Bainbridge has been studying what makes things memorable for over a decade. Through her research, she has found that there is a common thread about what most people remember—and even what we remember incorrectly (a phenomenon called the Mandela effect)—but most recently, why some visuals are intrinsically more memorable.

Bainbridge directs the Brain Bridge Lab, where her team has created a machine l...

If aliens landed on Earth tomorrow, how would we talk with them? Well, we already have a kind of creature on this planet we could attempt to talk to first, and in the last few years a team of renowned scientists have been exploring the ocean studying sperm whales to get that conversation going.

David Gruber is a professor of biology and environmental science at CUNY and the founder of Project CETI, an interdisciplinary scientific initiative that is using the latest developments in AI to understand, and possibly communicate with, sperm whales. The day when we break the...

We all know that extreme weather events like hurricanes are getting worse due to climate change, but what scientists would really like to know is: By how much worse exactly? This year a team of researchers argued that hurricanes have become so much more extreme due to climate change that we need to add a new category 6 to the Saffir-Simpson scale, which measures the wind speed of hurricanes.

One of those scientists was Michael Wehner from Lawrence Berkeley National Laboratory. Using the latest and fastest computers to model how a warming world is reshaping extreme weather events...

We've all heard the phrase "Manifest Your Destiny" when it comes to wanting that new promotion, figuring out a new career path or just trying to achieve that long-term goal. It turns out that the act of manifestation is not merely pseudoscience—it actually has a body of research in neuroscience to back it up. Dr. James Doty has been exploring this topic throughout his career; and offers scientific research as well as tools on how to manifest your goals in his new book, Mind Magic: The Neuroscience of Manifestation and How It Changes Everything.

James Doty is...

They’re perhaps the oldest questions in the science: Why do we die? And could we find a way to live forever? But for decades, anti-aging research was a “backwater” of the scientific community, consider too fanciful and unrealistic. That is until the last few years. Modern advances in biology have taught us a lot about how we age and why we die—could that knowledge help us turn back the clock?

In his new book, “Why We Die: The New Science of Ageing and the Quest for Immortality”, Nobel Prize-winning scientist Venki Ramakrishnan delves into the latest scien...

Every dog owner has faced the hard realization that their dog won’t live as long as they do, but we’ve all probably wondered: Why do some dogs live longer than others? It turns out that several factors are at play, according to the largest research study of dogs, known as The Dog Aging Project.

Prof. Daniel Promislow of the University of Washington is co-director of the project, which examines how biology, lifestyle and environment can increase both the health and lifespan of more than 50,000 dogs. We spoke with Promislow about whether we can help our dogs...

For more than a century, scientists have been studying Alzheimer’s disease and developing theories about its underlying cause. The leading theory for decades has been that abnormal amyloid plaques in the brains of those who suffer from the disease are the central cause. But, according one renowned Alzheimer’s researcher, this myopic focus is not only flawed, but may be holding back our search for a cure. 

Neurobiologist Karl Herrup argues that we need to go back to the drawing board, redefine the disease and understand the many factors that could cause it before we can race for...

Mosquito-borne diseases are one of the greatest global health threats, infecting around 700 million people every year with Zika virus, dengue fever, malaria and yellow fever — which can all be deadly if left untreated. Unfortunately, the mosquito population is not slowing down, and factors like climate change and increased global travel are broadening the mosquito's range. The effort to stop the mosquito is not an easy task; insecticides and vaccines can't completely stop the spread of these diseases. But instead of trying to kill mosquitoes, one nonprofit is taking a unique approach.

Scientist Scott O'Neill is founder and CE...

How do you stop a government from continuing to commit human rights abuses? You could take them to an international court of justice, or file a complaint at the UN. But none of those bodies have any enforcement power. Short of going to war, the only option on the table in most international situations is to name and shame. But is that strategy effective?

In her new book, “The Geopolitics of Shaming: When Human Rights Pressure Works and When It Backfires,” University of Chicago political scientist Rochelle Terman argues that there is a real dilemma to international huma...

The Supreme Court’s decision on whether Colorado can take former President Donald Trump off the ballot in the 2024 election may be one of the most consequential in its history. The case will turn on the court’s interpretation of Amendment 14, Section 3 of the Constitution, which bars any previous elected official from holding office if they participated in an insurrection. When making their case, Colorado followed the logic of a law review article co-authored last year by University of Chicago Prof. William Baude. The article drew a ton of attention, in part because Baude is a conservative legal scholar and member...

Language shapes our world. But when we speak, there is actually a secret conversation happening beyond our words. It’s happening not with our mouths—but with our hands.

Prof. Susan Goldin-Meadow is a distinguished scholar of psychology at the University of Chicago. Her research into deaf children who were never taught sign language led her to studying why the gestures we do all day may contain more information about our minds than we realize. Now she’s included all her insights in a new book, “Thinking With Your Hands—The Surprising Science Behind How Gestures Shape Our Thoughts...

The United States is facing a real mental health crisis. In the last few years, one possible treatment has gotten a lot of press: psychedelic drugs. But what is actually happening in a person’s brain when they take a psychedelic? Could understanding the biology and the chemistry allow us to make better and safer versions of these drugs—and maybe even create psychedelics without the hallucinations?

In this episode, we speak with Assoc. Prof. David E. Olson, founding director of the UC Davis Institute of Psychedelics and Neurotherapeutics. Olson and his lab have been researching the ther...

The Big Brains team is taking some time off during the holidays but for all those travelers out there heading home, we wanted to make sure you still had your favorite podcast in your feed. So, we’re resharing one of our most popular episodes ever. It’s about the science of happiness.

What is the key to living a happy and fulfilling life? The answer is actually quite simple, according to the two scholars behind the longest scientific study of happiness every conducted.

Beginning in 1938, the Harvard Study of Adult Development tracked three generations of f...

Here’s the question you’re going to be asking for the next 30 minutes: Did I freely choose to listen to this podcast, or did I actually have no choice at all? Most of us probably believe we have free will. We feel like we make decisions, and that each of us is responsible for the consequences of our actions. But what if that’s all just an illusion?

Robert Sapolsky is a renowned professor of biology and neurology at Stanford University, but he’s also the author of best-selling scientific books such as “Behave”. He’s always been fo...

Climate change can feel like an impossible crisis these days. Every week there is some new report about the irreversible damage we’re doing to our planet and the havoc it will bring to people’s lives. We all know cutting emissions is the solution, yet governments and companies seem no closer to meeting the goals that scientists say we must hit. It can feel hopeless.

There is one possible controversial solution to climate change many in the mainstream haven’t discussed. It’s so controversial, in fact, that some experts say we shouldn’t even be discussing it. But...

By now, you've probably heard about the dangers of PFAS “forever chemicals.” These chemicals are all around us—they're in waterproof hiking boots, electronics, nonstick pans and even our drinking water—but there's no way for them to break down in our environment. Epidemiological studies have linked to these chemicals to numerous diseases—from kidney cancer, liver cancer, obesity, decreased fertility and more.

American toxicologist Linda Birnbaum has been sounding the alarms about how PFAS are harming our health for the last few decades. She was previously the director of the National Institute for Environmental Health Sciences at the NIH an...

How many times have you heard this phrase: “Back in the day, people were nicer” or “People aren’t as kind as they used to be?” Most of us have experienced the feeling that people are becoming meaner over time, year after year. But is it true? Are people really less kind than they used to be?

That’s the question that has bothered psychologist Adam Mastroianni most of his life. He set out to find an answer—a search that recently culminated in a paper published in the journal Nature titled, “The Illusion of Moral Decline.” While the title ma...

Of the academic books that have become household names, “Freakonomics” must be at the top of the list. The 2005 book by University of Chicago scholar Steven Levitt and journalist Stephen Dubner created not only a whole new way of thinking about discovering answers to complex problems, but launched a media empire—from book sequel to a movie to a hit podcast.

On this special episode, we sat down with Levitt during the inaugural UCPN Podcast Festival, to talk about the legacy of Freakonomics. Almost 20 years later, he told our audience how he views himself as a “data scientis...

Since the Jan. 6, 2021 attack on the U.S. Capitol, University of Chicago Prof. Robert Pape has been closely observing the threats to our democracy. Now, the renowned terrorism expert says that violent ideas coming from a dedicated minority are moving from fringe to mainstream.

In 2021, Pape's team along with NORC at the University of Chicago launched the Dangers to Democracy tracker, an ongoing series of surveys to track Americans' thoughts and attitudes about political violence. In one recent survey, about 12 million Americans said they believe violence is justified to restore Trump to power. Still, Pape believes the da...

Free speech is probably one of the most polarizing public topics of debate. And those arguments only become more intense when it comes to free expression on college and university campuses. Should professors be allowed to say whatever they want? What about speakers being invited to campus? Who gets to say what is acceptable and unacceptable?

The University of Chicago has had a unique and long history of defending free expression, and this year is building upon that commitment by launching The Chicago Forum on Free Inquiry and Expression. That forum is being led by renowned UChicago...

Can you heal faster just by tricking your brain? Could you lose weight with only a change of mindset? Could you think yourself into being younger? If you think the answer to all these questions is no, you haven’t read the research from renowned Harvard University psychologist Ellen Langer.

Langer is a bit of a legend. She’s the first woman to ever receive tenure in psychology at Harvard, and her work has earned her the moniker: “The Mother of Mindfulness”. Her 40-year research career into the mind-body connection—and how mindfulness can hack that system—has delivere...

Reading is one of the most significant practices in the modern age of information, but it has a complicated history. Scientists began studying reading over a century ago; they built eye movement devices to study how fast and efficiently we read, and even proposed methods on the best ways to teach kids how to read. But all of this well-intentioned science led to various debates, from America's Reading Wars to today's anti-elite and anti-science movement. 

In a new book, The Science of Reading: Information, Media, and Mind in Modern America, Prof. Adrian Johns, chair of the Department of...

One of the first areas to be affected by AI has been science. Researchers have already started to integrate these new technologies into their work, but what does it mean to let these systems into our labs? Can they be trusted? And, if they so, how radically can they push science forward?

Prof. Rebecca Willett is the faculty director of AI at the University of Chicago Data Science Institute. She is at the forefront of thinking through how AI will change science, and in this episode, she examines the opportunities—and the dangers—of this rapidly emerging tech...

AI promises to change every part of our society, but one area that has already started to be affected is law. And AI may do more than just upend the profession of lawyers. One professor here at the University of Chicago believes that, with its ability to handle massive data sets, AI could be used to entirely change the law itself, making it personal for every individual based on how they live their lives. It’s a radical idea, but one we may need to start confronting sooner rather than later.

In the last few months AI has...

Science is facing a perplexing problem. Although there are far more scientists today than ever before, publishing research at a faster and faster pace, new and novel advancements have slowed not increased. But one expert at the University of Chicago thinks he may have found a way out of this progress standstill…artificial intelligence.

In the last few months AI has become the number one topic on everyone’s mind. This is the first episode of a three part series on the ways today's researchers think AI will build the world of tomorrow. As we continue our summ...

Everyone is talking about the upcoming summer blockbuster, Oppenheimer. We are always incredibly captivated by behind the curtain looks at some of the most momentous events in our history. Uncovering the secret details and hidden motivations of the people that have shaped our past. And all the buzz got me thinking about a fascinating prior episode of our show that did just that.

You may think you know the history of space travel, from Sputnik to NASA to our recent shift toward privatized space travel. But what if there was a lost history of our origins with...

Many cities in the US have been experiencing smoky and hazy skies lately. Some of you have probably been affected by poor air quality due to the ongoing wildfires in Canada that are causing pollution to travel as far as Chicago and New York. On a former episode of our podcast, we spoke with some of the leading experts on air pollution about how this problem has been getting worse and the cost we’re all paying for it.

We’re taking a summer break while we work on some special episodes and will be back in Augu...

Music plays an important role in all of our lives. But listening to music or playing an instrument is more than just a creative outlet or hobby — it’s also scientifically good for us. Research shows that music can stimulate new connections in our brains; keeping our cognitive abilities sharp and our memories alive.

In a new book entitled Every Brain Needs Music: The Neuroscience of Making and Listening to Music, Prof. Larry Sherman explores why we all need music for our mental wellbeing — and how it can even help us later in life.

Sherman is pro...

Everyone wishes they had a superpower. Well, it turns out you’ve had a secret power since you were a child, you just don’t know how to use it yet. That’s the power of language. In a fascinating new book, “Magic Words: What To Say To Get Your Way," Prof. Jonah Berger of the Wharton School uses massive data sets and machine learning to tease out the “magic words” that can transform our lives.

Could changing just a single word in your mind help you stick to that diet? Could mastering when to say “you” and when to say “...

If there is something both sides of the political aisle can agree on, it’s that there is something deeply wrong with health insurance in the United States. What they can’t agree on is how to fix it. The right blames everything on the Affordable Care Act, while those on the left say we need Healthcare For All. But what if there was another option?

In a recent paper published in JAMA, leading health economist and University of Chicago Provost Katherine Baicker lays out an innovative blueprint for health care—not to tinker with our system on the m...

Why do we fight? It’s a seemingly simple question, but it turns out the answers are surprising, deep and crucial to understanding our world. Considering how costly any conflict is in lives and money, why do wars happen at all? This is one of those episodes that will change how you view some of our most important issues, from the war in Ukraine, to understanding gang fights, and even a possible conflict with China.

We’re taking the week off to work on some truly special episodes coming out in the next few weeks, but thought this...

We often think our debates around sexuality and gender are a modern phenomenon. Some people argue that identities like trans and non-binary have only existed recently. But could the evidence for queer and gender-nonconforming lives actually stretch back centuries? 

In a recent book entitled Byzantine Intersectionality, Prof. Roland Betancourt of the University of California-Irvine uncovers an overlooked history from the Byzantine era. His work shows how surprisingly modern medieval conversations about sex and gender were—or, as he puts it, how medieval our modern conversations seem.

As extremist groups on the alt-right have begun to claim...

In the near future, birth defects, traumatic injuries, limb loss and perhaps even cancer could be cured through bioelectricity—electrical signals that communicate to our cells how to rebuild themselves. This innovative idea has been tested on flatworms and frogs by biologist Michael Levin, whose research investigates how bioelectricity provides the blueprint for how our bodies are built—and how it could be the future of regenerative medicine. 

Levin is professor of biology at Tufts University and director of the Tufts Center for Regenerative and Developmental Biology.

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Over his distinguished career, Nobel Prize-winning economist James Heckman has dedicated his research to understanding and solving the problem of inequality. He has closely studied how investing in early childhood development is linked to better outcomes—from higher earnings, to violence reduction, and even breaking the cycle of poverty.

His groundbreaking research has been applied across the globe—from Jamaica to Denmark and China, and it has given policymakers important insights into education, job-training programs, minimum wage legislation and more. His most recent work has centered on examining social mobility, and he’s help found an entire field...

In today's grocery stores, you can find more sugary snacks, artificial ingredients, and ultra-processed packaged foods. At the same time, the United States has seen an increase in obesity, which is costing our healthcare system, too. Nutritionist Marion Nestle says the problem today isn't that Americans don't know how to eat healthy, rather the food environment that we live in has made it much harder to do so.

In this episode, she discusses what policy changes are needed—from the way food studies are funded, to offering nutrition education in schools, to regulating the food industry better. Ne...

Link to the advertised Chicago Booth Review podcast: https://www.chicagobooth.edu/review/podcast?source=cbr-sn-cap-camp:podcast23-20230320 

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Mourning is an inevitable part of our human existence. But what exactly does it mean to mourn, and why is it an essential part of our well-being and survival? These questions have long fascinated Prof. Jonathan Lear, a philosopher at the University of Chicago. In his new book, Imagining the End: Mourning and Ethical Life, Lear unpacks why mourning contributes to a life well lived. He dissects the many ways we mourn in our everyday lives; when attachments are taken away from us, and even when we express gratitude. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com ...

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What is the key to living a happy and fulfilling life? The answer is actually quite simple, according to the two scholars behind the longest scientific study of happiness every conducted.

Beginning in 1938, the Harvard Study of Adult Development tracked three generations of families to uncover what contributed to their happiness. In their new book, The Good Life: Lessons from the World's Longest Scientific Study of Happiness, Robert Waldinger and Marc Schulz tell the stories behind their participants' lives and provide key insights on the recipe to happiness. 

Marc Schulz, a professor at Bryn Mawr C...

Almost a century ago, the origins of sleep science research began at the University of Chicago with the opening of the world's first sleep laboratory. Since then, sleep science has evolved into a multi-disciplinary field — with scientists focusing on diagnosing the causes of sleep disorders, to how sleep affects our metabolic health, and improving methods for good sleep hygiene. But at the core of sleep science, one fundamental question remains: Why do we sleep? In our special series, The Day Tomorrow Began, we speak with two of the world's leading sleep researchers: Assoc. Prof. Esra Tasali, director of the UChicago Sl...

As we approach the second anniversary of the Jan. 6 attack on the U.S. Capitol, we wanted to reflect on a few questions that many Americans are asking these days: Is democracy on the brink of the collapse? Why are U.S. politics so polarized? And are we headed for another civil war? These questions seem incredibly daunting, so we wanted to understand what the data really tell us. William Howell, a University of Chicago professor and director of the Center for Effective Government, has been thinking about these questions, along with political scientists across the country. In this episode...

As we head into 2023, many of us are setting our new year's resolutions and new goals for the year. It can be hard to stick to these resolutions or accomplish these goals, but there's a technique we can use to help us. We wanted to re-release our episode with Katy Milkman, a behavior scientist who wrote the best-selling book, How To Change: The Science of Getting From Where You Are To Where You Want To Be.

Katy Milkman is a professor at The Wharton School of the University of Pennsylvania, host of Charles Schwab’s popular behavioral econ...

In the last few years, we’ve witnessed the birth of an entirely new field of science: quantum technology. With the power to create unbreakable encryption, supercharge the development of AI, and radically expedite the development of drug treatments, quantum technology will revolutionize our world. Today is the day our quantum future is beginning. But what will the future look like, and what do we need to do to get there? In the latest edition of our special series The Day Tomorrow Began, we talk with two of the leading minds helping build the field of quantum technology from the gr...

We’re taking the week off to spend the holidays with our families, but we think this is a perfect moment to re-release one of our most important episodes. As we all dig into our delicious Thanksgiving dinners, we need to remember that not everyone is so lucky. Global hunger is still a massive problem facing our society. By 2050 humanity will have to make 50% more food in order to feed a growing population. That’s a lot, especially since we currently have trouble feeding the current population, and that food production is already responsible for about a third of the gree...

When you name your special series The Day Tomorrow Began, you inevitably have to ask yourself: just how far back are we going to go? If there’s one group of scholars who could tell us what the earliest possible day that “tomorrow” began is, it’s archaeologists. On this episode, we go back in time to learn about James Henry Breasted, a UChicago scholar who in the early 20th century revolutionized the field, founded the world-renowned Oriental Institute (the OI) and uncovered the roots of ancient civilizations. And we talk with leading scholars, who look to the future as the fiel...

It can seem like our culture is obsessed with our ability to focus. Why can’t we focus, how we can focus better, why is our lack of focus ruining society? There are best-selling books and apps that promise to teach us the secrets of paying attention. But what do we really know about what’s happening in the brain when we’re focused or not? In a fascinating set of studies, University of Chicago neuroscientist Monica Rosenberg is using fMRIs to study the science of attention and answer all sorts of questions about focus. In this episode we ask her: D...

Sometimes the biggest moments in scientific history happen in the most unlikely places. There’s no better example than the story of Nobel Prize-winning scientist Subrahmanyan Chandrasekhar, a longtime University of Chicago scholar whose pioneering research paved the way to the discovery of black holes. Chandrasekhar’s story is the first in a special series called “The Day Tomorrow Began,” in which we will examine the historical origins of some of the most breakthrough ideas to happen at the University of Chicago that have reshaped our world—and how scholars today are transforming our future. Joining us in exploring the history of...

This episode marks the official 100th episode of the Big Brains podcast. To celebrate this milestone, our Senior Producer Matt Hodapp joins host Paul M. Rand for a behind-the-scenes conversation about the philosophy behind the program, their favorite moments, as well as where the podcast has been—and where it’s going. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. The way we talk is not something we spend a lot of time thinking about. But, when it comes to communicating, what we’re saying may only be as important as how we say it. That’s what Prof. Katherine Kinzler of the University of Chicago argues in her new book, "How You Say It: Why You Talk the Way You Do...

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. What are the biggest questions in science today: Can we cure cancer, solve the climate crisis, make it to Mars? For Nobel laureate Jack Szostak, the biggest question is still much more fundamental: What is the origin of life? Jack Szostak has dedicated his lab to piecing together the complex puzzle of life’s origins on Earth. The story takes us...

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. For the more than 20 million people with a felony record, incarceration doesn’t end at the prison gate. They enter what University of Chicago scholar Reuben Jonathan Miller calls the “afterlife” of mass incarceration. Miller, an assistant professor at the Crown Family School of Social Work, Policy and Practice, is the author of a new book, Halfway Home: Race, Punishment a...

Hello Big Brains listeners! Our podcast is coming up on an important milestone … our 100th episode! As part of the month-long celebration, we’re looking back at some of our favorite episodes—highlighting a different world-changing idea or discovery each week. This week, we look back at our episode with UChicago economist, Raghuram Rajan. He became infamous for predicting the 2008 financial collapse three years before it happened. Rajan says that there are three pillars in our society: the state, the markets and the community. In his new book, he traces the history of how the state and markets have grown, while...

There have been myths and tropes about welfare since it was created. We often hear critics say that welfare discourages people from working — but are these claims really true? This debate often plays out through theory and anecdotes, yet it’s rare to get good data about the true effects of welfare. A groundbreaking paper by University of Chicago economist Manasi Deshpande does just that. It’s a first-of-its-kind study that tells a clear story about the life-long effects of one kind of welfare on employment and criminal involvement. The findings are thorough, surprising, and Deshpande hopes they will entirely refram...

Batteries have revolutionized our lives, especially the invention of rechargeable batteries, which have enabled us to have cellphones, laptops, and electric vehicles. But as we transition to more forms of green energy, we're facing a serious dilemma: Will our current lithium-ion batteries be able to sustain us? Battery scientist Shirley Meng says we need to explore different metals and elements that could last longer and charge faster. Meng is a chief scientist at the Argonne National Laboratory and a professor at the Pritzker School of Molecular Engineering at the University of Chicago. For the past two decades, she has been...

Do animals dream? If you’re a pet owner, it may seem obvious that your furry friends dream. Most of us have seen dogs running in their sleep or cats meowing during a nap. But this is an academic podcast and really proving that animals dream isn’t so simple. In his new book, When Animals Dream: The Hidden World of Animal Consciousness, philosopher David M. Pena-Guzman of San Francisco State University argues the science shows that animals really do dream, and that those dreams are evidence of consciousness. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for...

It’s not your imagination, summers have been getting hotter and hotter with extreme heatwaves occurring earlier and more frequently. But why is this happening and can we better predict heatwaves in advance to give people time to prepare? In June of 2021, an unprecedented heatwave shocked the Pacific Northwest and Canada. It ended up being one of the most deadly extreme weather events in the region. But no one could figure out how it occurred, until one Professor of Geophysical Science at the University of Chicago, Noboru Nakamura, saw it as an opportunity to test a new theoretical framework he ha...

We can’t always see the consequences of air pollution around us, but it’s costing us years off our lives. According to a new Air Quality Life Index report from the Energy Policy Institute at the University of Chicago (EPIC), air pollution is taking 2.2 years off the average global life expectancy. In some of the most polluted regions in the world, residents are expected to lose an average five years of their lives, if the current high levels of pollution persist. While smog seem like a difficult problem to tackle, some countries have proven it’s possible to clean up the...

When you think about corporate secrecy, nefarious shell companies and conspiratorial tax dodging, the state of Delaware probably doesn’t come to mind. We often think of exotic places like Panama or Bermuda, but the research of University of Chicago Adjunct Professor Hal Weitzman shows how it’s all happening right here in the United States. In his new book, What’s The Matter With Delaware?, Weitzman goes down the complex Delaware rabbit hole to discover how this tiny U.S. state became the incorporation capital of the world—uncovering everything from criminal conspiracies to wealthy tax avoidance to political dark mon...